Influence of the Copolymer Structure on Clustering of Magnetic Nanoparticles: Theranostic Drug Delivery Platforms

Abstract:

Here, we will discuss the influence of the copolymer structure on its interactions with magnetic nanoparticles (NPs) for the development of theranostic platforms. A functionalization of iron oxide NPs by amphiphilic copolymers may lead to either NP clustering or individual NP coating depending on the NP diameter and the copolymer structure. Magnetic NP clusters display enhanced uptake and release of doxorubicin (anticancer drug) compared to individually coated NPs most likely due to the higher retained polymer amount. In addition, clustering enhances a magnetic response as well as MRI properties due to interparticle interactions.