Abstract: Drug delivery via mucosal surfaces offers a number of advantages including improved drug bioavailability and possibility of targeting particular organs [1]. Dosage forms for transmucosal drug delivery should either be able to stick to mucosal surfaces and retain on them (mucoadhesion) or be able to penetrate through mucus layer to reach epithelial cells (mucopenetration). This lecture will describe the design and characterisation of polymeric materials with enhanced ability to adhere to mucosal surfaces or enhanced ability to penetrate through mucosal barriers. A range of novel mucoadhesive polymeric materials were synthesised to have special functional groups such as thiol- [2], acrylate- [3], methacrylate- [4] and maleimide- [5, 6] capable of forming covalent linkages with thiol groups present in mucins on mucosal surfaces. Mucopenetrating materials should have inert and stealth surface chemistry [7]. We have developed mucopenetrating nanoparticles using thiolated silica decorated with poly(2-oxazoline) short chains [8, 9] and demonstrated that the nature  of pendant groups strongly affects the ability of nanomaterials to penetrate. The application of these mucoadhesive and mucopenetrating polymeric systems for ocular, nasal, gastrointestinal and intravesical drug delivery will be discussed. 

 

References:

[1]. V.V. Khutoryanskiy, Mucoadhesive Materials and Drug Delivery Systems. John Wiley and Sons, ISBN 978-111-994-143-9, 2014, 1.

[2]. Cook M.T., S. Schmidt, E. Lee, W. Samprasit, P. Opanasopit, V.V. Khutoryanskiy, J. Mater. Chem. B 3, 6599 (2015).

[3]. R.P. Brannigan, V.V. Khutoryanskiy, Colloids and Surfaces B: Biointerfaces 155, 538 (2017).

[4]. O.M. Kolawole, W.-M. Lau, V.V. Khutoryanskiy, Int. J. Pharm. 550, 123 (2018).

[5]. P. Tonglairoum, R.P. Brannigan, P. Opanasopit, V.V. Khutoryanskiy, J. Mater. Chem. B. 4, 6581 (2016).

[6]. D.B. Kaldybekov, P. Tonglairoum, P. Opanasopit, V.V. Khutoryanskiy, Eur. J. Pharm. Sci. 111, 83 (2018).

[7]. V.V. Khutoryanskiy, Advanced Drug Delivery Reviews 124, 140 (2018).

[8]. E.D.H. Mansfield, K. Sillence, P. Hole, A.C. Williams, V.V. Khutoryanskiy, Nanoscale 7, 13671 (2015).

[9]. E.D.H. Mansfield, V.R. de la Rosa, R.M. Kowalczyk, I. Grillo, R. Hoogenboom,  K. Sillence, P. Hole, A.C. Williams,  V.V. Khutoryanskiy, Biomat. Sci. 4, 1318 (2016).

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