Interpolyelectrolyte complexes for gastrointestinal drug delivery

Abstract:

Interaction between reactive groups of (meth)acrylate copolymer pairs, which controlling the percent as well as the time of drugs release, inside matrices or spheres and within multilayer or combined coatings give the ways of designing timed and pH-sensitive systems with targeted drugs delivery into local parts of gastro-intestinal tract.  Analysis of these processes has a key significance for expanding ideas about the mechanisms regulating the transport of the drugs from prepared systems and about the ways of its modulation by changing the macromolecular parameters. Using (meth)acrylate polycomplexes is a promising way for developing new classes of pH-responsive drug carriers for oral drug delivery.

This work financially supported by the Russian Science Foundation (RSF) in the framework of research project № 20-65-46007.